Proteins PIF1 and PCNA gather at sites of DNA damage in SETX-deficient cells, indicating activation of the BIR repair system. LA JOLLA, CA—The DNA inside our cells is constantly being damaged, and one ...

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...

Researchers at the University of Bath have discovered how DNA damage caused by a faulty DNA protection and repair system can lead to neurodegenerative disorders such as motor neuron disease (MND).

Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy);(2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 ...

A diagram of the DRT3 system, showing Drt3a in yellow and Drt3b in blue. (Hyunbin Lee) Scientists have just discovered an ...

The human immune system is finely tuned to detect and destroy viral threats. But this same defense system can misfire. When ...

Like jewels in a vault, our precious genetic material is stored in the nucleus of a cell--sequestered away from potentially damaging cellular components and toxins so that no harm can come to it. Yet ...

"However, cells that dealt with the radiation-damaged DNA through other DNA repair methods survived the cell division process but did so by releasing byproducts of DNA repair into the cell. To the ...

Aston University bioscientist Dr John Reynolds has won a £125,000 Springboard grant from the Academy of Medical Sciences (AMS) for research into neurodegeneration caused by a rare genetic disease.